Keap1 Gene Summary [Mouse]
Enables disordered domain specific binding activity and identical protein binding activity. Involved in several processes, including cellular response to oxidative stress; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Acts upstream of or within several processes, including cellular response to interleukin-4; in utero embryonic development; and regulation of epidermal cell differentiation. Located in actin filament; endoplasmic reticulum; and inclusion body. Part of Cul3-RING ubiquitin ligase complex. Is expressed in eye and limb mesenchyme. Human ortholog(s) of this gene implicated in gallbladder cancer. Orthologous to human KEAP1 (kelch like ECH associated protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Keap1 |
| Official Name | kelch-like ECH-associated protein 1 [Source:MGI Symbol;Acc:MGI:1858732] |
| Ensembl ID | ENSMUSG00000003308 |
| Bio databases IDs | |
| Aliases | kelch-like ECH-associated protein 1 |
| Synonyms | INRF2, Kelch Like ECH-Associated Protein 1, KLHL19, mKIAA0132 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Keap1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Kelch motif
- transcription regulator
- BTB_POZ
- protein binding activity, bridging
- C-terminal heptad repeat domain
- transcription factor binding
- linker domain
- protein domain specific binding
- protein binding
- BACK (BTB and C-terminal Kelch) domain
- identical protein binding
- Galactose oxidase, central domain
- BTB And C-terminal Kelch
- Broad-Complex, Tramtrack and Bric a brac
- double glycine repeat domain
- BTB/POZ domain
- ETGE motif
- DGR region
- Kelch domain
- intervening region
- NTR domain
Pathways
Biological processes and signaling networks where the Keap1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- metastasis
- epithelial cancer
- epithelial neoplasia
- liver neoplasia
- systemic lupus erythematosus
- hyperkeratosis
- urothelial bladder carcinoma
- transitional cell bladder cancer
role in cell
- expression in
- growth
- apoptosis
- proliferation
- survival
- production in
- degradation in
- cell death
- activation in
- transactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoskeleton
- intracellular space
- perinuclear region
- focal adhesions
- Nucleus
- centrosome
- Endoplasmic Reticulum
- actin filaments
- midbody
- cytosol
- nucleoplasm
- cell-cell adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Keap1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- in utero embryonic development
- regulation of autophagy
- cellular response to interleukin-4
- cellular response to oxidative stress
- negative regulation of sequence-specific DNA binding transcription factor activity
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- regulation of epidermal cell differentiation
- protein ubiquitination
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- centriolar satellite
- cytosol
- endoplasmic reticulum
- midbody
- Cul3-RING ubiquitin ligase complex
- actin filament
- inclusion body
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- transcription factor binding