Nuak1 Gene Summary [Mouse]
Predicted to enable p53 binding activity and protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation; regulation of cell adhesion; and regulation of cellular senescence. Predicted to be located in cytoplasm; microtubule cytoskeleton; and nuclear lumen. Is expressed in several structures, including alimentary system; cardiovascular system; embryo ectoderm; nervous system; and renal cortex. Human ortholog(s) of this gene implicated in uterine fibroid. Orthologous to human NUAK1 (NUAK family kinase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nuak1 |
| Official Name | NUAK family, SNF1-like kinase, 1 [Source:MGI Symbol;Acc:MGI:1925226] |
| Ensembl ID | ENSMUSG00000020032 |
| Bio databases IDs | |
| Aliases | NUAK family, SNF1-like kinase, 1 |
| Synonyms | ARK5, AW494241, B230104P22Rik, KIAA0537, NUAK family kinase 1, NUAK family, SNF1-like kinase, 1, Omphk1, RGD1309956 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nuak1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- p53 binding
- protein binding
- Protein kinase domain
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- metastatic colorectal cancer
- neoplasia
- kidney disease
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
- organismal death
- esophageal squamous cell carcinoma
- esophageal squamous cell cancer
- endometriosis
- metastasis
role in cell
- expression in
- migration
- invasion by
- cell death
- transmembrane potential
- apoptosis
- proliferation
- invasion
- phosphorylation in
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- microtubule cytoskeleton
- fibrillar center
- Cytoplasm
- nucleoplasm
- early endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nuak1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of myosin-light-chain-phosphatase activity
- cell adhesion
- regulation of cell adhesion
- protein phosphorylation
- response to DNA damage stimulus
- regulation of cellular senescence
- regulation of cell proliferation
Cellular Component
Where in the cell the gene product is active
- nucleus
- microtubule cytoskeleton
- cytoplasm
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- p53 binding
- protein binding
- metal ion binding
- protein serine/threonine kinase activity