Akap11 Gene Summary [Mouse]
Enables protein kinase A regulatory subunit binding activity. Acts upstream of or within cortical actin cytoskeleton organization; protein localization to endosome; and renal water homeostasis. Predicted to be located in several cellular components, including cytosol; nucleolus; and peroxisome. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; eye; genitourinary system; immune system; and nervous system. Orthologous to human AKAP11 (A-kinase anchoring protein 11). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Akap11 |
| Official Name | A kinase (PRKA) anchor protein 11 [Source:MGI Symbol;Acc:MGI:2684060] |
| Ensembl ID | ENSMUSG00000022016 |
| Bio databases IDs | |
| Aliases | A kinase (PRKA) anchor protein 11 |
| Synonyms | 6330501D17, 6330501D17Rik, Akap, AKAP220, A-kinase anchoring protein 11, A kinase anchor protein 11, Gm80, mKIAA0629, PPP1R44, PRKA11 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Akap11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GSK-3beta binding domain
- protein kinase A binding
- protein phosphatase 1 binding
- protein kinase binding
- kinase regulator
- PP1 binding domain
- R2 binding domain
- protein binding
Pathways
Biological processes and signaling networks where the Akap11 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- bipolar disorder
- amyotrophic lateral sclerosis
- chronic lymphocytic leukemia
role in cell
- cell death
- migration
- production in
- formation
- formation in
- accumulation in
- elongation
- respiration in
- disruption
- elongation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- cell cortex
- Nucleus
- Plasma Membrane
- centrosome
- cytosol
- nucleoli
- peroxisomes
- cortical actin filaments
- cell membrane leading edge
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Akap11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cortical actin cytoskeleton organization
- renal water homeostasis
- protein localization in endosome
- protein localization
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- centrosome
- cytoplasm
- cytosol
- nucleolus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein kinase A regulatory subunit binding
- protein phosphatase 1 binding
- protein kinase A binding