Pcsk4 Gene Summary [Mouse]
Predicted to enable serine-type endopeptidase activity. Involved in fertilization and sperm capacitation. Acts upstream of or within acrosome reaction and binding activity of sperm to zona pellucida. Located in acrosomal membrane. Is expressed in early conceptus; epididymis; gonad; and neural retina. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Orthologous to human PCSK4 (proprotein convertase subtilisin/kexin type 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Pcsk4 |
| Official Name | proprotein convertase subtilisin/kexin type 4 [Source:MGI Symbol;Acc:MGI:97514] |
| Ensembl ID | ENSMUSG00000020131 |
| Bio databases IDs | |
| Aliases | proprotein convertase subtilisin/kexin type 4 |
| Synonyms | NEC 3, PC4, proprotein convertase subtilisin/kexin type 4, SPC5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pcsk4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Peptidase domain in the S8 and S53 families
- type VII secretion-associated serine protease mycosin
- FU
- Peptidase S8 pro-domain
- Subtilase family
- peptidase
- Proprotein convertase P-domain
- Furin-like repeats
- protein binding
- pro domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- Hutchinson-Gilford progeria syndrome
- epidermal hyperplasia
role in cell
- migration
- binding
- growth
- cell viability
- development
- activity
- capacitation
- fertility
- fertilization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- endoplasmic reticulum lumen
- acrosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pcsk4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- binding of sperm to zona pellucida
- sperm capacitation
- acrosome reaction
- reproductive process
- fertilization
- protein processing
- peptide hormone processing
Cellular Component
Where in the cell the gene product is active
- trans-Golgi network
- acrosomal membrane
- acrosomal vesicle
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- serine-type endopeptidase activity