Slc16a2 Gene Summary [Mouse]
Enables thyroid hormone transmembrane transporter activity. Involved in thyroid hormone transport. Acts upstream of or within with a negative effect on thyroid hormone generation and thyroid-stimulating hormone secretion. Located in apical plasma membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; cochlea; and limb. Used to study Allan-Herndon-Dudley syndrome. Human ortholog(s) of this gene implicated in Allan-Herndon-Dudley syndrome and intellectual disability. Orthologous to human SLC16A2 (solute carrier family 16 member 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc16a2 |
| Official Name | solute carrier family 16 (monocarboxylic acid transporters), member 2 [Source:MGI Symbol;Acc:MGI:1203732] |
| Ensembl ID | ENSMUSG00000033965 |
| Bio databases IDs | |
| Aliases | solute carrier family 16 (monocarboxylic acid transporters), member 2 |
| Synonyms | AHDS, DXS128, DXS128E, MCT 7, MCT 8, MRX22, solute carrier family 16 member 2, solute carrier family 16 (monocarboxylic acid transporters), member 2, XPCT |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc16a2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Major Facilitator Superfamily
- monocarboxylic acid transporter
- thyroid hormone transporter
- monocarboxylate transporter 1
- identical protein binding
- amino acid transporter
- transporter
Pathways
Biological processes and signaling networks where the Slc16a2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- Allan-Herndon syndrome
- hyperalgesia
- hereditary disorder
- androgenic alopecia
- mental retardation
- spastic paraplegia
- liver cancer
- hepatocellular carcinoma
- early missed abortion
role in cell
- proliferation
- cell viability
- development
- uptake in
- metabolism in
- transport in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- apical compartment
- basal compartment
- Endoplasmic Reticulum
- apical membrane
- basolateral membrane
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc16a2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- thyroid-stimulating hormone secretion
- thyroid hormone generation
- monocarboxylic acid transport
- negative regulation of neural precursor cell proliferation
- cellular amino acid metabolic process
- thyroid hormone metabolic process
- thyroid hormone transport
Cellular Component
Where in the cell the gene product is active
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- amino acid transmembrane transporter activity
- thyroid hormone transmembrane transporter activity
- monocarboxylic acid transmembrane transporter activity