Pcsk7 Gene Summary [Mouse]
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in protein processing. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in Golgi membrane and trans-Golgi network. Is expressed in early conceptus and oocyte. Orthologous to human PCSK7 (proprotein convertase subtilisin/kexin type 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pcsk7 |
| Official Name | proprotein convertase subtilisin/kexin type 7 [Source:MGI Symbol;Acc:MGI:107421] |
| Ensembl ID | ENSMUSG00000035382 |
| Bio databases IDs | |
| Aliases | proprotein convertase subtilisin/kexin type 7 |
| Synonyms | LPC, PC7, PC8, proprotein convertase subtilisin/kexin type 7, SPC7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pcsk7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Peptidase domain in the S8 and S53 families
- type VII secretion-associated serine protease mycosin
- Peptidase S8 pro-domain
- serine endopeptidase
- cytoplasmic domain
- stalk region
- Subtilase family
- peptidase
- transmembrane domain
- Proprotein convertase P-domain
- protein binding
- pro domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metabolic syndrome X
- breast carcinoma
- mammary neoplasm
- lung cancer
- abdominal aortic aneurysm
- carotid atherosclerosis
- hypothyroidism
- autosomal dominant polycystic kidney disease
role in cell
- molecular cleavage in
- replication in
- maturation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- endoplasmic reticulum lumen
- Golgi membrane
- trans Golgi network
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pcsk7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein processing
- peptide hormone processing
Cellular Component
Where in the cell the gene product is active
- trans-Golgi network
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- serine-type endopeptidase activity
- peptidase activity