Rc3h1 Gene Summary [Mouse]
Enables RNA binding activity and zinc ion binding activity. Involved in several processes, including P-body assembly; negative regulation of lymphocyte activation; and regulation of RNA metabolic process. Acts upstream of or within several processes, including T cell activation; hematopoietic or lymphoid organ development; and lymphocyte homeostasis. Located in P-body and cytoplasmic stress granule. Used to study peripheral T-cell lymphoma and systemic lupus erythematosus. Orthologous to human RC3H1 (ring finger and CCCH-type domains 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Rc3h1 |
| Official Name | RING CCCH (C3H) domains 1 [Source:MGI Symbol;Acc:MGI:2685397] |
| Ensembl ID | ENSMUSG00000040423 |
| Bio databases IDs | |
| Aliases | RING CCCH (C3H) domains 1 |
| Synonyms | 5730557L09RIK, FHL6, Gm551, IMDSHY, mKIAA2025, N28103, RGD1563512, RING CCCH (C3H) domains 1, ring finger and CCCH-type domains 1, RNF198, ROQUIN, Roquin-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rc3h1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- mRNA binding
- zinc finger of C3HC4-type, RING
- ubiquitin protein ligase activity
- enzyme
- Zinc finger C-x8-C-x5-C-x3-H type (and similar)
- protein binding
- RNA binding
- zinc finger
- Roquin II domain
- mRNA 3' UTR binding
- binding protein
- RING-type zinc-finger
- zinc ion binding
- Ring finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- double-stranded RNA binding
- ubiquitin-protein transferase activity
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- restless legs syndrome
- lupus erythematosus
- metabolic syndrome X
- insomnia
- dyslexia
- growth failure
- reperfusion injury
- nephritis
- immune dysregulation and systemic hyperinflammation syndrome
- atelectasis
role in cell
- expression in
- proliferation
- quantity
- production in
- number
- phosphorylation in
- homeostasis
- differentiation
- generation
- M1 polarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic mRNA processing body
- stress granule
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rc3h1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
- 3'-UTR-mediated mRNA destabilization
- nuclear-transcribed mRNA catabolic process
- spleen development
- lymph node development
- regulation of mRNA stability
- negative regulation of T-helper cell differentiation
- T cell homeostasis
- negative regulation of B cell proliferation
- regulation of germinal center formation
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
- negative regulation of germinal center formation
- regulation of T cell receptor signaling pathway
- T cell receptor signaling pathway
- protein polyubiquitination
- negative regulation of activated T cell proliferation
- B cell homeostasis
- nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
- ubiquitin-dependent protein catabolic process
- posttranscriptional regulation of gene expression
- regulation of miRNA metabolic process
- T cell proliferation
- cellular response to interleukin-1
- cytoplasmic mRNA processing body assembly
- negative regulation of T-helper 17 cell differentiation
Cellular Component
Where in the cell the gene product is active
- cytoplasmic stress granule
- cytoplasmic mRNA processing body
Molecular Function
What the gene product does at the molecular level
- miRNA binding
- ubiquitin-protein ligase activity
- zinc ion binding
- protein binding
- RNA binding
- double-stranded RNA binding
- RNA stem-loop binding
- mRNA binding
- mRNA 3'-UTR binding