Cfap410 Gene Summary [Mouse]
Acts upstream of or within cilium assembly and smoothened signaling pathway. Located in ciliary basal body and photoreceptor connecting cilium. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in axial spondylometaphyseal dysplasia. Orthologous to human CFAP410 (cilia and flagella associated protein 410). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cfap410 |
| Official Name | cilia and flagella associated protein 410 [Source:MGI Symbol;Acc:MGI:1915134] |
| Ensembl ID | ENSMUSG00000020284 |
| Bio databases IDs | |
| Aliases | cilia and flagella associated protein 410 |
| Synonyms | 1810043G02Rik, C21orf2, cilia and flagella associated protein 410, D10Jhu13e, LOC100996591, LRRC76, RDMS, RGD1309594, SMDAX, YF5/A2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cfap410 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- occurring C-terminal to leucine-rich repeats
- Leucine rich repeat
- protein binding
- Leucine Rich repeats (2 copies)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- retinal dystrophy without macular staphyloma
- susceptibility to amyotrophic lateral sclerosis
- axial spondylometaphyseal dysplasia
- retinal dystrophy with or without macular staphyloma
- amyotrophic lateral sclerosis
- retinitis pigmentosa
- retinal dystrophy
- cone dystrophy
- cone-rod dystrophy
- Leber congenital amaurosis type 1
role in cell
- organization
- assembly
- homologous recombination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- non-motile cilium
- Plasma Membrane
- basal bodies
- Golgi Apparatus
- Mitochondria
- cytosol
- connecting cilia
- nucleoplasm
- neurites
- photoreceptor outer segments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cfap410 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- cilium morphogenesis
- cytoskeleton organization
- smoothened signaling pathway
- response to DNA damage stimulus
Cellular Component
Where in the cell the gene product is active
- photoreceptor connecting cilium
- cytoplasm
- cilium basal body
- intracellular membrane-bounded organelle
- mitochondrion
- cytosol
- plasma membrane
- photoreceptor outer segment
Molecular Function
What the gene product does at the molecular level
- protein binding