Nsg2 Gene Summary [Mouse]
Predicted to enable clathrin light chain binding activity. Involved in regulation of postsynaptic membrane neurotransmitter receptor levels. Located in Golgi cis cisterna membrane and multivesicular body membrane. Is active in glutamatergic synapse and postsynaptic density membrane. Is expressed in several structures, including axial skeleton; intestine; nasal epithelium; nervous system; and retina. Orthologous to human NSG2 (neuronal vesicle trafficking associated 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nsg2 |
| Official Name | neuron specific gene family member 2 [Source:MGI Symbol;Acc:MGI:1202070] |
| Ensembl ID | ENSMUSG00000020297 |
| Bio databases IDs | |
| Aliases | neuron specific gene family member 2 |
| Synonyms | CALY3, HMP19, neuronal vesicle trafficking associated 2, neuron specific gene family member 2, Neurospecific gene family membrane protein 2, P19 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nsg2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- D1 dopamine receptor-interacting protein (calcyon)
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- cytoplasmic vesicle membrane
- cellular membrane
- Plasma Membrane
- endosomes
- Golgi Apparatus
- synaptic membrane
- Golgi membrane
- Golgi stacks
- trans Golgi network
- lysosomal compartment
- early endosomes
- late endosomes
- multivesicular bodies
- Golgi cisternae
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nsg2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- clathrin coat assembly
- endosomal transport
- dopamine receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- dendrite
- early endosome
- cytoplasmic vesicle membrane
- endosome
- membrane
- late endosome
- Golgi apparatus
- lysosomal lumen
- multivesicular body membrane
- trans-Golgi network membrane
Molecular Function
What the gene product does at the molecular level
- clathrin light chain binding
- protein binding