Asb3 Gene Summary [Mouse]
Predicted to be involved in negative regulation of canonical Wnt signaling pathway; positive regulation of JNK cascade; and protein targeting to chloroplast. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in cerebral cortex; cerebral cortex ventricular layer; and trunk somite. Orthologous to several human genes including ASB3 (ankyrin repeat and SOCS box containing 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Asb3 |
| Official Name | ankyrin repeat and SOCS box-containing 3 [Source:MGI Symbol;Acc:MGI:1929749] |
| Ensembl ID | ENSMUSG00000020305 |
| Bio databases IDs | |
| Aliases | ankyrin repeat and SOCS box-containing 3 |
| Synonyms | 2400011J03Rik, ankyrin repeat and SOCS box-containing 3, LOC100361167 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Asb3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SOCS box
- transcription regulator
- Ankyrin repeats (many copies)
- Ankyrin repeats (3 copies)
- SOCS
- protein binding
- Ankyrin repeat
- ankyrin repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Asb3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cardiac muscle contraction
- intracellular signal transduction
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- T-tubule
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding