Tspyl5 Gene Summary [Mouse]
Predicted to enable chromatin binding activity and histone binding activity. Predicted to be involved in several processes, including cellular response to gamma radiation; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and positive regulation of protein ubiquitination. Predicted to be active in chromatin and nucleus. Orthologous to human TSPYL5 (TSPY like 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tspyl5 |
| Official Name | testis-specific protein, Y-encoded-like 5 [Source:MGI Symbol;Acc:MGI:2442458] |
| Ensembl ID | ENSMUSG00000038984 |
| Bio databases IDs | |
| Aliases | testis-specific protein, Y-encoded-like 5 |
| Synonyms | 6330530B20, E130308C19Rik, testis-specific protein, Y-encoded-like 5, TSPY-like 5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tspyl5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Nucleosome assembly protein (NAP)
- PTZ00007
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- glioblastoma cancer
- epithelial cancer
- renal clear cell adenocarcinoma
- renal clear cell cancer
- glioblastoma
- endometrial adenocarcinoma
- endometrial adenocarcinoma formation
- endometrial cancer
- liver cancer
role in cell
- proliferation
- expression in
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tspyl5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to gamma radiation
- positive regulation of cell proliferation
- positive regulation of protein ubiquitination
- nucleosome assembly
- positive regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- protein binding
- histone binding
- chromatin binding