Gon4l Gene Summary [Mouse]
Enables transcription corepressor activity. Involved in negative regulation of DNA-templated transcription. Acts upstream of or within B cell differentiation. Located in nucleus. Used to study salivary gland cancer. Orthologous to several human genes including GON4L (gon-4 like). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gon4l |
| Official Name | gon-4-like (C.elegans) [Source:MGI Symbol;Acc:MGI:1917579] |
| Ensembl ID | ENSMUSG00000054199 |
| Bio databases IDs | |
| Aliases | gon-4-like (C.elegans) |
| Synonyms | 1500041I23Rik, 2610100B20Rik, 3632445O20Rik, 5430404N14Rik, 5830417I10Rik, AA387005, Dingo, FLJ20203, GON-4, gon-4 like, LOC100505728, YARP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gon4l often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SANT
- transcription regulator
- SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
- transcription co-repressor
- protein binding
- Paired amphipathic helix repeat
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- diabetic retinopathy
- gastric carcinoma
- gastric epithelial cancer
- autosomal recessive nonsyndromic mental retardation
regulated by
- tetradecanoylphorbol acetate
- Gstp1 (includes others)
role in cell
- apoptosis
- expression in
- differentiation
- number
- development
- synthesis in
- fragmentation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- fibrillar center
- Nucleus
- nucleoplasm
- nucleoli
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gon4l gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of transcription, DNA-dependent
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- transcription cofactor activity