Cracr2a Gene Summary [Mouse]
Predicted to enable GTP binding activity; GTPase activity; and calcium ion binding activity. Involved in T-helper 1 cell differentiation and positive regulation of JNK cascade. Acts upstream of or within positive regulation of calcium ion transport. Predicted to be located in several cellular components, including Golgi apparatus; Weibel-Palade body; and immunological synapse. Is expressed in several structures, including alimentary system; bladder; cerebellum; male reproductive gland or organ; and trigeminal nerve. Orthologous to human CRACR2A (calcium release activated channel regulator 2A). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cracr2a |
| Official Name | calcium release activated channel regulator 2A [Source:MGI Symbol;Acc:MGI:2685919] |
| Ensembl ID | ENSMUSG00000061414 |
| Bio databases IDs | |
| Aliases | calcium release activated channel regulator 2A |
| Synonyms | calcium release activated channel regulator 2A, EFCAB4B, FLJ33046, Gm1073, Gm462, LOC102723813, RAB46, RGD1563719 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cracr2a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-hand domain pair
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- 50S ribosome-binding GTPase
- GTPase
- calcium ion binding
- EFh
- enzyme
- protein binding
- Ras subfamily of RAS small GTPases
- EF hand like domain
- ADP-ribosylation factor family
- small GTP-binding protein domain
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- ADP-ribosylation factor
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- periodontitis
- acute myeloid leukemia
- combined immunodeficiency
- male infertility
- nonalcoholic fatty liver disease
regulated by
- EGF
- Ca2+
role in cell
- cell death
- differentiation
- transport
- clustering in
- localization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- secretory granule lumen
- Extracellular Space
- Plasma Membrane
- vesicles
- immunological synapses
- microtubule organizing centers
- Golgi membrane
- trans Golgi network
- secretory granules
- clathrin-coated vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cracr2a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- store-operated calcium entry
- positive regulation of calcium ion transport
- adaptive immune response
- activation of store-operated calcium channel activity
Cellular Component
Where in the cell the gene product is active
- microtubule organizing center
- specific granule lumen
- cytoplasm
- membrane
- Golgi membrane
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- calcium ion binding
- GTPase activity