Tmem97 Gene Summary [Mouse]
Enables oxysterol binding activity. Predicted to be involved in several processes, including cholesterol homeostasis; positive regulation of lipoprotein transport; and regulation of intracellular cholesterol transport. Predicted to be located in several cellular components, including lysosome; nuclear membrane; and rough endoplasmic reticulum. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including alimentary system; central nervous system; limb; male reproductive gland or organ; and skeleton. Orthologous to human TMEM97 (transmembrane protein 97). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tmem97 |
| Official Name | transmembrane protein 97 [Source:MGI Symbol;Acc:MGI:1916321] |
| Ensembl ID | ENSMUSG00000037278 |
| Bio databases IDs | |
| Aliases | transmembrane protein 97 |
| Synonyms | 1810014L12Rik, Ai852985, D11Bhm182e, Loc303330, MAC30, RGD1307423, S2R, sigma2R, Sigma 2 Receptor, transmembrane protein 97, σ 2 Receptor |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tmem97 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- oxysterol binding
- cholesterol binding
- transmembrane 6 superfamily member 1, member 2, and similar proteins
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- colon epithelial cancer
- preeclampsia
- organismal death
- age-related macular degeneration
- colon carcinoma
- gastric carcinoma
- gastric epithelial cancer
role in cell
- proliferation
- phosphorylation in
- expression in
- tamoxifen resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- Plasma Membrane
- lysosome
- Endoplasmic Reticulum
- Mitochondria
- nuclear envelope
- rough endoplasmatic reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tmem97 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of wound healing
- regulation of cell growth
- regulation of intracellular cholesterol transport
- regulation of intracellular lipid transport
- cholesterol homeostasis
Cellular Component
Where in the cell the gene product is active
- nuclear membrane
- rough endoplasmic reticulum membrane
- rough endoplasmic reticulum
- endoplasmic reticulum
- plasma membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- cholesterol binding
- oxysterol binding