Kremen1 Gene Summary [Mouse]
Predicted to enable transmembrane signaling receptor activity. Involved in several processes, including negative regulation of axon regeneration; negative regulation of canonical Wnt signaling pathway; and negative regulation of ossification. Located in neuronal cell body. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb ectoderm; and sensory organ. Human ortholog(s) of this gene implicated in ectodermal dysplasia 13. Orthologous to human KREMEN1 (kringle containing transmembrane protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kremen1 |
| Official Name | kringle containing transmembrane protein 1 [Source:MGI Symbol;Acc:MGI:1933988] |
| Ensembl ID | ENSMUSG00000020393 |
| Bio databases IDs | |
| Aliases | kringle containing transmembrane protein 1 |
| Synonyms | ECTD13, KREMEN, kringle containing transmembrane protein 1, KRM1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kremen1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- KR
- WSC domain
- present in yeast cell wall integrity and stress response component proteins
- CUB
- protein binding
Pathways
Biological processes and signaling networks where the Kremen1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- breast carcinoma
- progression free survival
- hereditary disorder
- diverticular disease
- preeclampsia
- polydactyly
- hair/tooth type ectodermal dysplasia type 13
- polycystic kidney disease
- mucopolysaccharidosis type IVB
role in cell
- expression in
- apoptosis
- quantity
- number
- abnormal morphology
- regeneration
- surface area
- ossification by
- communication
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kremen1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of canonical Wnt receptor signaling pathway
- negative regulation of axon regeneration
- cell communication
- multicellular organismal development
- limb development
- regulation of canonical Wnt receptor signaling pathway
- apoptotic process
- Wnt receptor signaling pathway
- negative regulation of ossification
Cellular Component
Where in the cell the gene product is active
- membrane
- neuronal cell body
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding