Med7 Gene Summary [Mouse]
Predicted to enable transcription coregulator activity. Predicted to contribute to ubiquitin protein ligase activity. Acts upstream of or within somatic stem cell population maintenance. Part of mediator complex. Is expressed in cerebral cortex; genitourinary system; and tibialis anterior. Orthologous to human MED7 (mediator complex subunit 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Med7 |
| Official Name | mediator complex subunit 7 [Source:MGI Symbol;Acc:MGI:1913463] |
| Ensembl ID | ENSMUSG00000020397 |
| Bio databases IDs | |
| Aliases | mediator complex subunit 7 |
| Synonyms | 1110063B05Rik, ARC34, CRSP33, CRSP9, hMED7, MED34, mediator complex subunit 7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Med7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-activator
- ubiquitin protein ligase activity
- MED7 protein
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypothyroidism
- infection by HIV-1
- productive infection by HIV-1
regulates
- DNA promoter
- DNA endogenous promoter
- RNA polymerase II
- TBP
- mediator
role in cell
- expression in
- binding in
- replication in
- reverse transcription in
- reverse transcription
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Med7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription elongation from RNA polymerase II promoter
- RNA polymerase II transcriptional preinitiation complex assembly
- positive regulation of transcription initiation from RNA polymerase II promoter
- somatic stem cell maintenance
- transcription initiation from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- nucleus
- core mediator complex
- nuclear body
- ubiquitin ligase complex
- mediator complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription coactivator activity