Med11 Gene Summary [Mouse]
Predicted to enable transcription coregulator activity. Predicted to contribute to ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Predicted to be located in nucleus. Predicted to be part of core mediator complex; mediator complex; and ubiquitin ligase complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and integumental system. Orthologous to human MED11 (mediator complex subunit 11). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Med11 |
| Official Name | mediator complex subunit 11 [Source:MGI Symbol;Acc:MGI:1913422] |
| Ensembl ID | ENSMUSG00000018923 |
| Bio databases IDs | |
| Aliases | mediator complex subunit 11 |
| Synonyms | 1110030J09Rik, HSPC296, mediator complex subunit 11, NDDRSB, RGD1563202 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Med11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Mediator complex protein
- transcription regulator
- ubiquitin protein ligase activity
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neurodegeneration with developmental delay, early respiratory failure, myoclonic seizures, and brain abnormalities
- productive infection by HIV-1
regulates
role in cell
- expression in
- replication in
- transactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Med11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription elongation from RNA polymerase II promoter
- RNA polymerase II transcriptional preinitiation complex assembly
- positive regulation of transcription initiation from RNA polymerase II promoter
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- core mediator complex
- ubiquitin ligase complex
- mediator complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription cofactor activity