Ccnc Gene Summary [Mouse]
Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity and identical protein binding activity. Predicted to contribute to ubiquitin protein ligase activity. Predicted to be involved in several processes, including G0 to G1 transition; negative regulation of Notch signaling pathway; and regulation of primary metabolic process. Part of mediator complex. Is expressed in central nervous system; limb; retina; and tongue. Orthologous to human CCNC (cyclin C). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ccnc |
| Official Name | cyclin C [Source:MGI Symbol;Acc:MGI:1858199] |
| Ensembl ID | ENSMUSG00000028252 |
| Bio databases IDs | |
| Aliases | cyclin C |
| Synonyms | CG1C, CycC, cyclin C, hSRB11, SARCOLUMENIN, SRB11, SRCA |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ccnc often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cyclin box
- Cyclin box fold superfamily
- ubiquitin protein ligase activity
- cyclin ccl1
- Cyclin C-terminal domain
- enzyme
- domain present in cyclins, TFIIB and Retinoblastoma
- protein binding
- identical protein binding
Pathways
Biological processes and signaling networks where the Ccnc gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hereditary gingival fibromatosis
- autosomal recessive polycystic kidney disease
- hypoplasia
- growth failure
role in cell
- expression in
- apoptosis
- activation in
- adhesion
- accumulation in
- survival
- phagocytosis by
- permeabilization
- differentiation
- autophagy in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- Mitochondria
- cytoplasmic particles
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ccnc gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G0 to G1 transition
- negative regulation of Notch signaling pathway
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cyclin-dependent protein kinase holoenzyme complex
- mediator complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- cyclin-dependent protein kinase regulator activity
- protein binding