Acot7 Gene Summary [Mouse]
Enables identical protein binding activity and long-chain fatty acyl-CoA hydrolase activity. Acts upstream of or within fatty acid catabolic process. Located in several cellular components, including cytosol; mitochondrial matrix; and neuronal cell body. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human ACOT7 (acyl-CoA thioesterase 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Acot7 |
| Official Name | acyl-CoA thioesterase 7 [Source:MGI Symbol;Acc:MGI:1917275] |
| Ensembl ID | ENSMUSG00000028937 |
| Bio databases IDs | |
| Aliases | acyl-CoA thioesterase 7 |
| Synonyms | 2410041A17Rik, ACH1, ACT, acyl-CoA thioesterase 7, AU014716, BACH, Brain Acyl-coa Hydrolase, CTE-II, CTE-IIa, CTE-IIb, hBACH, LACH, LACH1, MTE-II |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Acot7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- palmitoyl-CoA hydrolase
- Thioesterase superfamily
- acyl-CoA binding
- protein homodimerization
- hot_dog
- enzyme
- protein binding
- identical protein binding
- acyl-CoA hydrolase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- colon carcinoma
- colon epithelial cancer
- renal cell carcinoma
- renal cell cancer
- androgenic alopecia
regulates
- fatty acid
- triacylglycerol
- lipid reactive oxygen species
- malondialdehyde
- oleic acid
- coenzyme A
- medium chain fatty acid
- palmitoleic acid
- palmitic acid
role in cell
- cell death
- proliferation
- production in
- quantity
- colony formation by
- synthesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
- mitochondrial matrix
- nucleoplasm
- neurites
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Acot7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- acyl-CoA metabolic process
- fatty acid catabolic process
- medium-chain fatty-acyl-CoA catabolic process
- medium-chain fatty acid biosynthetic process
- coenzyme A biosynthetic process
- palmitic acid biosynthetic process
- long-chain fatty-acyl-CoA catabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- mitochondrion
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein homodimerization activity
- fatty-acyl-CoA binding
- long-chain fatty acyl-CoA binding
- long-chain acyl-CoA hydrolase activity
- carboxylic ester hydrolase activity