Rdh14 Gene Summary [Mouse]

Enables all-trans-retinol dehydrogenase (NADP+) activity. Involved in retinol metabolic process. Located in mitochondrion. Orthologous to human RDH14 (retinol dehydrogenase 14). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Rdh14
Official Name
retinol dehydrogenase 14 (all-trans and 9-cis) [Source:MGI Symbol;Acc:MGI:1920402]
Ensembl ID
ENSMUSG00000020621
Bio databases IDs NCBI: 105014 Ensembl: ENSMUSG00000020621
Aliases retinol dehydrogenase 14 (all-trans and 9-cis)
Synonyms 3110030G19RIK, PAN2, retinol dehydrogenase 14, retinol dehydrogenase 14 (all-trans and 9-cis), RGD1565196, SDR7C4
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rdh14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • NADP-retinol dehydrogenase
  • Rossmann-fold NAD(P)(+)-binding proteins
  • enzyme
  • protein binding
  • Enoyl-(Acyl carrier protein) reductase
  • short chain dehydrogenase
  • alcohol dehydrogenase (NADP)

Pathways

Biological processes and signaling networks where the Rdh14 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • pH resistant lipid raft fraction
  • Endoplasmic Reticulum
  • Mitochondria
  • cytosol
  • endoplasmic reticulum membrane
  • nucleoplasm

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Rdh14 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • osteoblast differentiation
  • retinol metabolic process

Cellular Component

Where in the cell the gene product is active
  • endoplasmic reticulum membrane
  • nucleus
  • membrane
  • cytosol
  • endoplasmic reticulum
  • lysosomal membrane
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • steroid dehydrogenase activity
  • NADP-retinol dehydrogenase activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.