Rnf170 Gene Summary [Mouse]
Enables ubiquitin protein ligase activity. Acts upstream of or within several processes, including adult walking behavior; protein K48-linked ubiquitination; and toll-like receptor 3 signaling pathway. Predicted to be active in endoplasmic reticulum membrane. Used to study hereditary ataxia. Human ortholog(s) of this gene implicated in autosomal dominant sensory ataxia 1 and hereditary spastic paraplegia 85. Orthologous to human RNF170 (ring finger protein 170). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rnf170 |
| Official Name | ring finger protein 170 [Source:MGI Symbol;Acc:MGI:1924983] |
| Ensembl ID | ENSMUSG00000013878 |
| Bio databases IDs | |
| Aliases | ring finger protein 170 |
| Synonyms | 6720407G21RIK, ADSA, AI481227, LOC100361542, ring finger protein 170, SNAX1, SPG85 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rnf170 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RING-type zinc-finger
- ubiquitin protein ligase activity
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- zinc finger of C3HC4-type, RING
- Ring finger
- enzyme
- Ring finger domain
- protein binding
- Protein of unknown function (DUF1232)
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- autosomal recessive spastic paraplegia type 85
- autosomal dominant sensory ataxia type 1
- neurodevelopmental disorder
- spastic paraplegia
- infection by HIV-1
regulates
- proteasome
- ITPR1
role in cell
- ubiquitination in
- mono-ubiquitination in
- K63 polyubiquitination in
- K48 polyubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rnf170 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of toll-like receptor 3 signaling pathway
- protein K48-linked ubiquitination
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding