Rdh14 Gene Summary [Rat]
Predicted to enable all-trans-retinol dehydrogenase (NADP+) activity. Predicted to act upstream of or within retinol metabolic process. Predicted to be located in cytosol; endoplasmic reticulum; and nucleoplasm. Orthologous to human RDH14 (retinol dehydrogenase 14). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rdh14 |
| Official Name | retinol dehydrogenase 14 [Source:RGD Symbol;Acc:1565196] |
| Ensembl ID | ENSRNOG00000039551 |
| Bio databases IDs | |
| Aliases | retinol dehydrogenase 14 |
| Synonyms | 3110030G19RIK, PAN2, retinol dehydrogenase 14, retinol dehydrogenase 14 (all-trans and 9-cis), RGD1565196, SDR7C4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rdh14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NADP-retinol dehydrogenase
- Rossmann-fold NAD(P)(+)-binding proteins
- enzyme
- protein binding
- Enoyl-(Acyl carrier protein) reductase
- short chain dehydrogenase
- alcohol dehydrogenase (NADP)
Pathways
Biological processes and signaling networks where the Rdh14 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- endoplasmic reticulum membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rdh14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- osteoblast differentiation
- retinol metabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nucleus
- membrane
- cytosol
- endoplasmic reticulum
- lysosomal membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- steroid dehydrogenase activity
- NADP-retinol dehydrogenase activity