Grhl1 Gene Summary [Mouse]
Enables transcription cis-regulatory region binding activity. Involved in epidermis development. Acts upstream of or within desmosome organization; establishment of skin barrier; and regulation of keratinocyte differentiation. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Orthologous to human GRHL1 (grainyhead like transcription factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Grhl1 |
| Official Name | grainyhead like transcription factor 1 [Source:MGI Symbol;Acc:MGI:2182540] |
| Ensembl ID | ENSMUSG00000020656 |
| Bio databases IDs | |
| Aliases | grainyhead like transcription factor 1 |
| Synonyms | Grainyhead, grainyhead-like transcription factor 1, LBP-32, LOC108351211, LOC686566, MGR, NH32, Tcfcp2l2, TFCP2L2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Grhl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- nucleic acid binding
- transcription factor binding
- chromatin binding
- protein binding
- sequence-specific DNA binding
- identical protein binding
- zDHHC ankyrin repeat binding domain
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- protein homodimerization
- transcription factor activity
- CP2 transcription factor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- epithelial cancer
- epithelial basal cell carcinoma
- breast carcinoma
- prostatic carcinoma
- prostate cancer
- Down syndrome
- obsessive-compulsive disorder
regulates
- RNA polymerase II
- DNA promoter
- DNA endogenous promoter
- GRHL1
role in cell
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Grhl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of keratinocyte differentiation
- desmosome organization
- epidermis development
- positive regulation of transcription from RNA polymerase II promoter
- establishment of skin barrier
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- intracellular membrane-bounded organelle
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- chromatin DNA binding
- identical protein binding
- protein homodimerization activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity