Tfcp2l1 Gene Summary [Mouse]
Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including determination of adult lifespan; epithelial cell maturation; and negative regulation of transcription by RNA polymerase II. Located in cytoplasm; membrane; and nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; heart; and limb. Orthologous to human TFCP2L1 (transcription factor CP2 like 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Tfcp2l1 |
| Official Name | transcription factor CP2-like 1 [Source:MGI Symbol;Acc:MGI:2444691] |
| Ensembl ID | ENSMUSG00000026380 |
| Bio databases IDs | |
| Aliases | transcription factor CP2-like 1 |
| Synonyms | 1810030F05Rik, 4932442M07Rik, AA575098, Cp2l1, CRTR1, D930018N21Rik, LBP-9, TCFCP2L1, Tcfcp2-related transcriptional repressor 1, transcription factor CP2-like 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tfcp2l1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- double-stranded DNA binding
- nucleic acid binding
- SAM (Sterile alpha motif )
- SAM domain (Sterile alpha motif)
- protein binding
- sequence-specific DNA binding
- CP2 transcription factor
Pathways
Biological processes and signaling networks where the Tfcp2l1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic kidney disease
- testicular germ cell tumor
- germ cell neoplasia
- renal clear cell adenocarcinoma
- renal clear cell cancer
- thyroid carcinoma
- epithelial thyroid cancer
- Behcet disease
- diabetic nephropathy
- gout
role in cell
- expression in
- organization
- transactivation in
- self-renewal
- maturation
- pluripotency
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cellular membrane
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tfcp2l1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- positive regulation of growth
- epithelial cell maturation
- determination of adult lifespan
- cell morphogenesis
- salivary gland development
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
- cytoplasm organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- membrane
- chromatin
Molecular Function
What the gene product does at the molecular level
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity