Zbtb1 Gene Summary [Mouse]
Enables protein homodimerization activity. Involved in positive regulation of T cell mediated immunity; positive regulation of lymphocyte differentiation; and thymus development. Acts upstream of or within B cell differentiation and T cell differentiation in thymus. Predicted to be located in nuclear body and nuclear membrane. Predicted to be active in nucleoplasm. Is expressed in several structures, including central nervous system; female reproductive system; jaw bone; submandibular gland primordium; and urinary system. Orthologous to human ZBTB1 (zinc finger and BTB domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zbtb1 |
| Official Name | zinc finger and BTB domain containing 1 [Source:MGI Symbol;Acc:MGI:2442326] |
| Ensembl ID | ENSMUSG00000033454 |
| Bio databases IDs | |
| Aliases | zinc finger and BTB domain containing 1 |
| Synonyms | 9430077A12, AI256369, Bsg2, C430003J21RIK, zinc finger and BTB domain containing 1, ZNF909 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zbtb1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Broad-Complex, Tramtrack and Bric a brac
- BTB_POZ
- protein homodimerization
- BTB/POZ domain
- protein binding
- protein heterodimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- eczema
regulated by
- decitabine
- metribolone
- GnRH analog
- resiquimod
- SUMO2
- CpG ODN 2006
regulates
- RNA polymerase II
- DNA endogenous promoter
- DNA promoter
- RAD18
role in cell
- quantity
- differentiation
- development
- DNA damage response
- remodeling
- double negative stage 3
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nuclear bodies
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zbtb1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA transcription from RNA polymerase II promoter
- DNA repair
- B cell differentiation
- T cell differentiation in thymus
- protein homooligomerization
- response to DNA damage stimulus
- regulation of immune system process
- thymus development
- negative regulation of transcription from RNA polymerase II promoter
- positive regulation of natural killer cell differentiation
- chromatin remodeling
- positive regulation of T cell mediated immunity
- innate immune response
- positive regulation of T cell differentiation
- cellular response to UV
- positive regulation of pro-T cell differentiation
- regulation of cytokine production
- translesion synthesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear membrane
- nuclear body
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein homodimerization activity
- protein heterodimerization activity
- metal ion binding
- K63-linked polyubiquitin binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription