Rpl8 Gene Summary [Mouse]
A structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Located in cytoplasm. Part of cytosolic large ribosomal subunit. Is active in synapse. Is expressed in liver left lobe and liver right lobe. Orthologous to human RPL8 (ribosomal protein L8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rpl8 |
| Official Name | ribosomal protein L8 [Source:MGI Symbol;Acc:MGI:1350927] |
| Ensembl ID | ENSMUSG00000003970 |
| Bio databases IDs | |
| Aliases | ribosomal protein L8 |
| Synonyms | L8, L8-60S, LOC108348142, ribosomal protein L8, uL2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rpl8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ribosomal Proteins L2, RNA binding domain
- structural constituent of ribosome
- rRNA binding
- Ribosomal Proteins L2, C-terminal domain
- protein binding
- ribosomal protein L2, bacterial/organellar
- RNA binding
Pathways
Biological processes and signaling networks where the Rpl8 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- interchromatin granule cluster fractions
- postsynaptic region
- ribosome
- Nucleus
- cytosol
- nucleoplasm
- nucleoli
- nuclear envelope
- synapse
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rpl8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytoplasmic translation
- translation
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- focal adhesion
- cytosolic ribosome
- cytoplasm
- membrane
- cytosol
- cytosolic large ribosomal subunit
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- structural constituent of ribosome
- rRNA binding