Tfg Gene Summary [Mouse]
Predicted to enable identical protein binding activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Predicted to be located in cytosol and intracellular membrane-bounded organelle. Predicted to be active in endoplasmic reticulum exit site. Is expressed in several structures, including branchial arch; limb; nasal process; and nervous system. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 57. Orthologous to human TFG (trafficking from ER to golgi regulator). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tfg |
| Official Name | Trk-fused gene [Source:MGI Symbol;Acc:MGI:1338041] |
| Ensembl ID | ENSMUSG00000022757 |
| Bio databases IDs | |
| Aliases | Trk-fused gene |
| Synonyms | HMSNO, HMSNP, LOC103690095, SPG57, TF6, trafficking from ER to golgi regulator, Trk fused, Trk-fused gene, TRKT3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tfg often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- coiled-coil domain
- protein binding
- identical protein binding
- PB1
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- rheumatoid arthritis
- hereditary disorder
- gait disturbance
- Charcot-Marie-Tooth disease
- proximal type hereditary motor and sensory neuropathy
- autosomal recessive spastic paraplegia type 57
- neonatal late-onset sepsis
role in cell
- proliferation
- growth
- colony formation
- trafficking
- signaling by
- transformation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- cellular membrane
- Endoplasmic Reticulum
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tfg gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ER to Golgi vesicle-mediated transport
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- COPII vesicle coating
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- intracellular membrane-bounded organelle
- cytosol
- endoplasmic reticulum exit site
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding