Camkk1 Gene Summary [Mouse]
Predicted to enable calcium/calmodulin-dependent protein kinase activity and calmodulin binding activity. Predicted to be involved in intracellular signal transduction. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm. Is expressed in central nervous system and retina. Orthologous to human CAMKK1 (calcium/calmodulin dependent protein kinase kinase 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Retained Intron |
| Official Symbol | Camkk1 |
| Official Name | calcium/calmodulin-dependent protein kinase kinase 1, alpha [Source:MGI Symbol;Acc:MGI:1891766] |
| Ensembl ID | ENSMUSG00000020785 |
| Bio databases IDs | |
| Aliases | calcium/calmodulin-dependent protein kinase kinase 1, alpha |
| Synonyms | 4732414G09Rik, calcium/calmodulin-dependent protein kinase kinase 1, calcium/calmodulin-dependent protein kinase kinase 1, alpha, calcium/calmodulin-dependent protein kinase kinase 1, α, Camkk, CAMKKA, CaM-KK alpha, CaM-KK α |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Camkk1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- autoinhibitory protein domain
- calmodulin binding
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- protein binding
- Protein kinase domain
- calmodulin regulated protein kinase
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Camkk1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epileptic seizure
- tinnitus
- thromboembolism
role in cell
- G1 phase
- expression in
- production in
- cell death
- phosphorylation in
- growth
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Camkk1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- calmodulin binding
- protein binding
- calmodulin-dependent protein kinase activity