Luc7l3 Gene Summary [Mouse]
Predicted to enable mRNA binding activity. Predicted to be involved in mRNA splice site recognition. Predicted to be located in nuclear speck. Predicted to be part of U1 snRNP and U2-type prespliceosome. Is expressed in central nervous system and retina. Orthologous to human LUC7L3 (LUC7 like 3 pre-mRNA splicing factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Luc7l3 |
| Official Name | LUC7-like 3 (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1914934] |
| Ensembl ID | ENSMUSG00000020863 |
| Bio databases IDs | |
| Aliases | LUC7-like 3 (S. cerevisiae) |
| Synonyms | 3300001P08Rik, CISPLATIN RESISTANCE, CRA, CREAP-1, CROP, hLuc7A, LUC7A, LUC7-like 3 pre-mRNA splicing factor, LUC7-like 3 (S. cerevisiae), OA48-18, RGD1307981 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Luc7l3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- mRNA binding
- LUC7 N_terminus
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epilepsy
- chronic kidney disease
- sarcoidosis
regulates
- PTGS2
- NFkB (complex)
role in cell
- activation in
- apoptosis
- survival
- berzosertib resistance
- transactivation in
- ceralasertib resistance
- progression in
- progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- spliceosomes
- nucleoplasm
- nuclear speckles
- nuclear granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Luc7l3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- mRNA splice site selection
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear speck
- U2-type prespliceosome
- U1 snRNP
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- RNA binding
- mRNA binding