Srpk3 Gene Summary [Mouse]
Enables protein serine/threonine kinase activity. Involved in muscle tissue development. Acts upstream of or within protein phosphorylation and skeletal muscle tissue development. Predicted to be active in cytoplasm and nucleus. Is expressed in tail mesenchyme; tongue; and vertebral axis musculature. Orthologous to human SRPK3 (SRSF protein kinase 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Srpk3 |
| Official Name | serine/arginine-rich protein specific kinase 3 [Source:MGI Symbol;Acc:MGI:1891338] |
| Ensembl ID | ENSMUSG00000002007 |
| Bio databases IDs | |
| Aliases | serine/arginine-rich protein specific kinase 3 |
| Synonyms | MSSK-1, serine/arginine-rich protein specific kinase 3, SRSF protein kinase 3, STK23, XLID114 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Srpk3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- Protein Kinases, catalytic domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- X-linked mental retardation
- centronuclear myopathy
- congenital myopathy
- productive infection by HIV-1
role in cell
- expression in
- growth
- proliferation
- differentiation
- degeneration
- signaling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Srpk3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of mRNA processing
- skeletal muscle tissue development
- cell differentiation
- muscle tissue development
- peptidyl-serine phosphorylation
- intracellular signal transduction
- spliceosomal complex assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- protein serine/threonine kinase activity