Tmem107 Gene Summary [Mouse]
Involved in several processes, including embryonic digit morphogenesis; non-motile cilium assembly; and protein localization to ciliary transition zone. Acts upstream of or within several processes, including craniofacial suture morphogenesis; detection of nodal flow; and roof of mouth development. Located in ciliary transition zone. Is expressed in brain; nasal cavity epithelium; node; and pharynx. Human ortholog(s) of this gene implicated in Meckel syndrome 13 and orofaciodigital syndrome XVI. Orthologous to human TMEM107 (transmembrane protein 107). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tmem107 |
| Official Name | transmembrane protein 107 [Source:MGI Symbol;Acc:MGI:1914160] |
| Ensembl ID | ENSMUSG00000020895 |
| Bio databases IDs | |
| Aliases | transmembrane protein 107 |
| Synonyms | 1110004B13Rik, 2810049P21Rik, GRVS638, JBTS29, LOC687595, MKS13, PRO1268, transmembrane protein 107 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tmem107 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Transmembrane protein
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- leukoencephalopathy, brain calcifications, and cysts
- palatal shelves fail to meet at midline
- cleft lip
- orofaciodigital syndrome
- Meckel syndrome type 13
- orofaciodigital syndrome type 16
- anophthalmia
- exencephaly
- Joubert syndrome type 29
- hypoplasia
regulated by
- dimethyl n-oxalyl-glycine
- Ebna3c
- MYO6
- EGLN
role in cell
- apoptosis
- upregulation in
- formation
- formation in
- necroptosis
- assembly
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- ciliary transition zone
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tmem107 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- detection of nodal flow
- cilium morphogenesis
- palate development
- regulation of gene expression
- craniofacial suture morphogenesis
- embryonic digit morphogenesis
- neural tube patterning
Cellular Component
Where in the cell the gene product is active
- membrane
- ciliary transition zone
- TCTN-B9D complex
Molecular Function
What the gene product does at the molecular level
- protein binding