Sar1a Gene Summary [Mouse]
Predicted to enable G protein activity and amino acid sensor activity. Acts upstream of or within negative regulation of cargo loading into COPII-coated vesicle and vesicle-mediated transport. Located in Golgi apparatus and sarcoplasmic reticulum. Is expressed in several structures, including genitourinary system; liver; nervous system; retina nuclear layer; and skeletal musculature. Orthologous to human SAR1A (secretion associated Ras related GTPase 1A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sar1a |
| Official Name | secretion associated Ras related GTPase 1A [Source:MGI Symbol;Acc:MGI:98230] |
| Ensembl ID | ENSMUSG00000020088 |
| Bio databases IDs | |
| Aliases | secretion associated Ras related GTPase 1A |
| Synonyms | 1600019H17Rik, masra2, SAR1, SARA, SARA1, secretion associated Ras related GTPase 1A, secretion associated, Ras related GTPase 1A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sar1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ras family
- smad binding domain
- small monomeric GTPase
- 50S ribosome-binding GTPase
- switch2 region
- enzyme
- protein binding
- Sar1p-like members of the Ras-family of small GTPases
- ADP-ribosylation factor family
- small GTP-binding protein domain
- GTPase domain
- ADP-ribosylation factor
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute graft-vs-host disease
- abdominal aortic aneurysm
- hypocholesterolemia
role in cell
- apoptosis
- expression in
- production in
- formation
- beta-oxidation in
- growth
- synthesis in
- S phase
- response by
- fitness
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- sarcoplasmic reticulum
- Golgi Apparatus
- Endoplasmic Reticulum
- cytosol
- endoplasmic reticulum membrane
- endoplasmic reticulum exit sites
- lysosome membrane
- early endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sar1a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane organization
- ER to Golgi vesicle-mediated transport
- vesicle organization
- positive regulation of protein exit from endoplasmic reticulum
- cargo loading into COPII-coated vesicle
- intracellular protein transport
- regulation of COPII vesicle coating
- lipoprotein transport
- COPII vesicle coating
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- Golgi cisterna membrane
- cytosol
- endoplasmic reticulum exit site
- COPII vesicle coat
- lysosomal membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity
- small monomeric GTPase activity