Atp11c Gene Summary [Mouse]
Predicted to enable phosphatidylethanolamine flippase activity and phosphatidylserine flippase activity. Involved in phospholipid translocation; positive regulation of B cell differentiation; and pre-B cell differentiation. Predicted to be located in early endosome membrane; endoplasmic reticulum membrane; and recycling endosome membrane. Predicted to be part of phospholipid-translocating ATPase complex. Predicted to be active in endoplasmic reticulum; plasma membrane; and recycling endosome. Is expressed in choroid invagination; cortical plate; diencephalon roof plate; and metencephalon part of 4th ventricle choroid plexus. Human ortholog(s) of this gene implicated in X-linked congenital hemolytic anemia. Orthologous to human ATP11C (ATPase phospholipid transporting 11C). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atp11c |
| Official Name | ATPase, class VI, type 11C [Source:MGI Symbol;Acc:MGI:1859661] |
| Ensembl ID | ENSMUSG00000062949 |
| Bio databases IDs | |
| Aliases | ATPase, class VI, type 11C |
| Synonyms | A330005H02RIK, AI315324, Atp11c-ps1, ATPase, class VI, type 11C, ATPase IG, ATPase IQ, ATPase phospholipid transporting 11C, ATPIG, ATPIQ, HACXL, Ig, RGD1564481 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Atp11c often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid transporter
- Mg2+-ATPase
- Phospholipid-translocating ATPase N-terminal
- protein binding
- ATPase, P-type (transporting), HAD superfamily, subfamily IC
- Phospholipid-translocating P-type ATPase C-terminal
- lipid transporter
- Endosomal/lysosomal potassium channel TMEM175
- aminophospholipid transporter
- phospholipid-translocating P-type ATPase, flippase
- Cation transport ATPase (P-type)
- Haloacid Dehalogenase-like Hydrolases
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection
- X-linked congenital hemolytic anemia
- colitis
- B cell lymphopenia
regulates
- phospholipid
- ion
- phosphatidylserine
role in cell
- number
- quantity
- differentiation
- exposure in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Atp11c gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phospholipid translocation
- ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- early endosome membrane
- endoplasmic reticulum
- recycling endosome
- recycling endosome membrane
- lysosomal membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATPase activity
- ATP binding
- protein binding