Ston2 Gene Summary [Mouse]
Predicted to enable clathrin adaptor activity. Involved in regulation of endocytosis. Acts upstream of or within hematopoietic progenitor cell differentiation. Located in clathrin-coated vesicle and synaptic vesicle. Orthologous to human STON2 (stonin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ston2 |
| Official Name | stonin 2 [Source:MGI Symbol;Acc:MGI:1918272] |
| Ensembl ID | ENSMUSG00000020961 |
| Bio databases IDs | |
| Aliases | stonin 2 |
| Synonyms | 4933401N24RIK, AI425999, AW544599, EG666955, Gm8378, RGD1311502, STN2, STNB, STNB2, stonin 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ston2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- stonin homology domain
- mu 2 homology domain
- AP_MHD_Cterm
- Mu-homology domain
- NPF motif
- Adaptor complexes medium subunit family
- protein binding
- proline rich domain
- Stonin 2
Pathways
Biological processes and signaling networks where the Ston2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
role in cell
- differentiation
- accumulation in
- abnormal morphology
- abnormal quantity
- endocytosis by
- endocytosis
- uncoating
- recycling
- paired-pulse facilitation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- peripheral membrane fraction
- membrane fraction
- presynaptic regions
- perinuclear region
- cellular membrane
- cytosol
- nucleoli
- synaptic vesicles
- nerve ending
- clathrin-coated vesicles
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ston2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- clathrin-mediated endocytosis
- synaptic vesicle endocytosis
- regulation of endocytosis
Cellular Component
Where in the cell the gene product is active
- synaptic vesicle
- cytosol
- AP-2 adaptor complex
- nucleolus
- neuron projection
Molecular Function
What the gene product does at the molecular level
- protein binding
- clathrin adaptor activity