Cops4 Gene Summary [Mouse]
Predicted to be involved in protein deneddylation. Part of COP9 signalosome. Is expressed in central nervous system; male reproductive system; and urinary system. Orthologous to human COPS4 (COP9 signalosome subunit 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cops4 |
| Official Name | COP9 signalosome subunit 4 [Source:MGI Symbol;Acc:MGI:1349414] |
| Ensembl ID | ENSMUSG00000035297 |
| Bio databases IDs | |
| Aliases | COP9 signalosome subunit 4 |
| Synonyms | COP9 signalosome subunit 4, CSN4, D5Ertd774e, SGN4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cops4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CSN4/RPN5/eIF3a helix turn helix domain
- NEDD8-specific protease
- motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
- PCI domain
- peptidase
- protein binding
Pathways
Biological processes and signaling networks where the Cops4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell junction
- Nucleus
- cytosol
- nucleoplasm
- nuclear speckles
- synaptic vesicles
- synaptosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cops4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein neddylation
- protein deneddylation
- regulation of protein neddylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nuclear speck
- synaptic vesicle
- cytosol
- cell junction
- signalosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- NEDD8-specific protease activity