STON2

STON2 Gene Summary

This gene encodes a protein which is a membrane protein involved in regulating endocytotic complexes. The protein product is described as one of the clathrin-associated sorting proteins, adaptor molecules which ensure specific proteins are internalized. The encoded protein has also been shown to participate in synaptic vesicle recycling through interaction with synaptotagmin 1 required for neurotransmission. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Details

Type
Protein Coding
Official Symbol
STON2
Official Name
stonin 2 [Source:HGNC Symbol;Acc:HGNC:30652]
Ensembl ID
ENSG00000140022
Bio databases IDs NCBI: 85439 Ensembl: ENSG00000140022
Aliases stonin 2, stoned B homolog 2 (Drosophila)
Synonyms
4933401N24RIK,AI425999,AW544599,EG666955,Gm8378,RGD1311502,STN2,STNB,STNB2,stonin 2
Species
Human, Homo sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • stonin homology domain
  • mu 2 homology domain
  • AP_MHD_Cterm
  • Mu-homology domain
  • NPF motif
  • Adaptor complexes medium subunit family
  • protein binding
  • proline rich domain
  • Stonin 2

Pathways

Biological processes and signaling networks where the STON2 gene plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
  • CAPZA2
  • SYT2
  • RHOJ
  • RHOU
  • AP2B1
  • LSR
  • EPS15
  • MYO18A
  • VIRMA
  • RHOD
disease
regulated by
  • TP63
  • TOR1A
  • SOD1
  • ziritaxestat
  • COPS4
  • poly rI:rC-RNA
  • paraquat
  • BMP4
  • activin (family)
  • maneb
regulates
  • TF
  • AP2
  • SYT1
  • EGF
  • Adaptor protein 2
  • synaptotagmin
  • LDL
role in cell
  • differentiation
  • accumulation in
  • abnormal morphology
  • abnormal quantity
  • endocytosis by
  • endocytosis
  • uncoating
  • recycling
  • paired-pulse facilitation

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • peripheral membrane fraction
  • membrane fraction
  • presynaptic regions
  • perinuclear region
  • cellular membrane
  • cytosol
  • nucleoli
  • synaptic vesicles
  • nerve ending
  • clathrin-coated vesicles
  • cytosolic fraction

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the STON2 gene, providing context for its role in the cell.

BIOLOGICAL PROCESS

Functions and activities the gene product is involved in
  • clathrin-mediated endocytosis
  • synaptic vesicle endocytosis
  • regulation of endocytosis

CELLULAR COMPONENT

Where in the cell the gene product is active
  • synaptic vesicle
  • cytosol
  • AP-2 adaptor complex
  • nucleolus
  • neuron projection

MOLECULAR FUNCTION

What the gene product does at the molecular level
  • protein binding
  • clathrin adaptor activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.