Nemf Gene Summary [Mouse]
Predicted to enable alpha-aminoacyl-tRNA binding activity; ribosomal large subunit binding activity; and tRNA binding activity. Involved in CAT tailing. Predicted to be located in cytosol. Predicted to be part of RQC complex. Predicted to be active in cytosolic ribosome. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and hemolymphoid system gland. Used to study neuromuscular disease and neuropathy. Orthologous to human NEMF (nuclear export mediator factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nemf |
| Official Name | nuclear export mediator factor [Source:MGI Symbol;Acc:MGI:1918305] |
| Ensembl ID | ENSMUSG00000020982 |
| Bio databases IDs | |
| Aliases | nuclear export mediator factor |
| Synonyms | 1500011I12Rik, 4933405E14Rik, IDDSAPN, nuclear export mediator factor, NY-CO-1, RQC2, SDCCAG1, SDCCAG1 isoform 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nemf often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NFACT protein C-terminal domain
- NFACT protein RNA binding domain
- protein binding
- ribosomal large subunit binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- intellectual developmental disorder with speech delay and axonal peripheral neuropathy
- hereditary disorder
- gestational diabetes mellitus
- insulin-dependent diabetes mellitus
regulated by
- Ribosomal Subunit 60s
regulates
- protein-protein complex
role in cell
- nuclear export in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- ribosome
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nemf gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nuclear export
- macromolecular complex assembly
- rescue of stalled ribosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosolic ribosome
- cytosol
Molecular Function
What the gene product does at the molecular level
- ribosomal large subunit binding
- tRNA binding