NEMF Gene Summary [Human]
This gene encodes a component of the ribosome quality control complex. The encoded protein facilitates the recognition and ubiquitination of stalled 60S subunits by the ubiquitin ligase listerin. A similar protein in fly functions as a tumor suppressor. [provided by RefSeq, Jul 2016]
Details
| Type | Protein Coding |
| Official Symbol | NEMF |
| Official Name | nuclear export mediator factor [Source:HGNC Symbol;Acc:HGNC:10663] |
| Ensembl ID | ENSG00000165525 |
| Bio databases IDs | |
| Aliases | nuclear export mediator factor, caliban homolog (Drosophila) |
| Synonyms | 1500011I12Rik, 4933405E14Rik, IDDSAPN, nuclear export mediator factor, NY-CO-1, RQC2, SDCCAG1, SDCCAG1 isoform 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NEMF often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NFACT protein C-terminal domain
- NFACT protein RNA binding domain
- protein binding
- ribosomal large subunit binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- intellectual developmental disorder with speech delay and axonal peripheral neuropathy
- hereditary disorder
- gestational diabetes mellitus
- insulin-dependent diabetes mellitus
regulated by
- Ribosomal Subunit 60s
regulates
- protein-protein complex
role in cell
- nuclear export in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- ribosome
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NEMF gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nuclear export
- macromolecular complex assembly
- rescue of stalled ribosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosolic ribosome
- cytosol
Molecular Function
What the gene product does at the molecular level
- ribosomal large subunit binding
- tRNA binding