Thoc5 Gene Summary [Mouse]
Enables mRNA binding activity. Involved in primitive hemopoiesis. Acts upstream of or within several processes, including negative regulation of macrophage differentiation; regulation of mRNA export from nucleus; and regulation of stem cell division. Located in nucleus. Is expressed in brain; early conceptus; and inner cell mass. Human ortholog(s) of this gene implicated in breast carcinoma. Orthologous to human THOC5 (THO complex subunit 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Thoc5 |
| Official Name | THO complex 5 [Source:MGI Symbol;Acc:MGI:1351333] |
| Ensembl ID | ENSMUSG00000034274 |
| Bio databases IDs | |
| Aliases | THO complex 5 |
| Synonyms | 1700060C24Rik, A430085L24RIK, C22orf19, FMIP, fSAP79, PK1.3, Sgk2, THO complex 5, THO complex subunit 5, TREX90 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Thoc5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Fms binding domain
- cytoplasmic domain
- mRNA binding
- protein binding
- Fms-interacting protein/Thoc5
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- liver cancer
- hepatocellular carcinoma
role in cell
- expression in
- morphology
- apoptosis
- differentiation
- survival
- alternative splicing in
- cell division
- morphogenesis
- number
- multinucleation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
- telomeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Thoc5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA export from nucleus
- RNA splicing
- mRNA processing
- monocyte differentiation
- primitive hemopoiesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromosome, telomeric region
- cytoplasm
- THO complex
- transcription export complex
- THO complex part of transcription export complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- mRNA binding