Ltn1 Gene Summary [Mouse]
Enables ubiquitin protein ligase activity. Involved in protein autoubiquitination. Predicted to be part of RQC complex. Predicted to be active in cytosolic ribosome. Is expressed in several structures, including genitourinary system; gut; nervous system; sensory organ; and thymus. Orthologous to human LTN1 (listerin E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ltn1 |
| Official Name | listerin E3 ubiquitin protein ligase 1 [Source:MGI Symbol;Acc:MGI:1926163] |
| Ensembl ID | ENSMUSG00000052299 |
| Bio databases IDs | |
| Aliases | listerin E3 ubiquitin protein ligase 1 |
| Synonyms | 4930528H02Rik, C21orf10, C21orf98, Listerin, listerin E3 ubiquitin protein ligase 1, RNF160, Zfp294, ZNF294 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ltn1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ring finger
- ubiquitin protein ligase activity
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- ubiquitin-protein transferase activity
- enzyme
- Ring finger domain
- protein binding
- FANCL C-terminal domain
- RING-H2 zinc finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- ribosome
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ltn1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- rescue of stalled ribosome
- protein autoubiquitination
Cellular Component
Where in the cell the gene product is active
- cytosolic ribosome
- cytosol
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- ribosomal large subunit binding