Bcl2l14 Gene Summary [Mouse]
Predicted to enable protein kinase binding activity. Predicted to be involved in apoptotic process and positive regulation of extrinsic apoptotic signaling pathway. Predicted to act upstream of or within regulation of apoptotic process. Predicted to be located in cytosol. Is expressed in early embryo; genitourinary system; gut; and submandibular gland primordium. Orthologous to human BCL2L14 (BCL2 like 14). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bcl2l14 |
| Official Name | BCL2-like 14 (apoptosis facilitator) [Source:MGI Symbol;Acc:MGI:1914063] |
| Ensembl ID | ENSMUSG00000030200 |
| Bio databases IDs | |
| Aliases | BCL2-like 14 (apoptosis facilitator) |
| Synonyms | 4930452K23Rik, 4933405K19Rik, 9030625M01Rik, BCL2 like 14, BCLG, LOC101928224, LOC102724106 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bcl2l14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Bcl-2_like
- protein kinase binding
- Bcl-2 homology 2 domain
- Bcl-2 homology 3 domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- diabetes mellitus
- systemic lupus erythematosus
- COVID-19
- lung adenocarcinoma
- lung adenocarcinoma formation
- pemphigus foliaceus
- male pattern hair loss
role in cell
- apoptosis
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- organelle
- Mitochondria
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bcl2l14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- apoptotic process
- regulation of extrinsic apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- intracellular organelle
- membrane
- cytosol
- endomembrane system
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding