Rab43 Gene Summary [Mouse]
Predicted to enable GTPase activity. Acts upstream of or within cellular response to type II interferon. Located in phagocytic vesicle. Is expressed in several structures, including adrenal gland; central nervous system; genitourinary system; gut; and vascular system. Orthologous to human RAB43 (RAB43, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rab43 |
| Official Name | RAB43, member RAS oncogene family [Source:MGI Symbol;Acc:MGI:1917084] |
| Ensembl ID | ENSMUSG00000030055 |
| Bio databases IDs | |
| Aliases | RAB43, member RAS oncogene family |
| Synonyms | 1810048P08Rik, 2500004H21Rik, AW490415, RAB11B, RAB41, RAB43, member RAS oncogene family |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rab43 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- small GTP-binding protein domain
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- Rab subfamily of small GTPases
- GTPase
- enzyme
- protein binding
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
- Ras subfamily of RAS small GTPases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular nanovesicle
- vesicles
- Golgi Apparatus
- trans Golgi network
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rab43 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- autophagic vacuole assembly
- Golgi organization
- virion assembly
- retrograde transport, plasma membrane to Golgi
- phagosome maturation
- cellular response to interferon-gamma
- intracellular protein transport
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- phagocytic vesicle
- phagocytic vesicle membrane
- endomembrane system
- Golgi apparatus
- trans-Golgi network membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity