Rnf128 Gene Summary [Mouse]
Enables ubiquitin protein ligase activity. Acts upstream of or within negative regulation of cytokine production. Located in Golgi apparatus; endoplasmic reticulum; and late endosome. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; nervous system; and sensory organ. Orthologous to human RNF128 (ring finger protein 128). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rnf128 |
| Official Name | ring finger protein 128 [Source:MGI Symbol;Acc:MGI:1914139] |
| Ensembl ID | ENSMUSG00000031438 |
| Bio databases IDs | |
| Aliases | ring finger protein 128 |
| Synonyms | 1300002C13Rik, GRAIL, Greul1, LOC100503383, LOC108348295, LOC315910, RGD1566282, ring finger protein 128 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rnf128 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PHD zinc finger
- cell penetrating signal sequence
- ubiquitin protein ligase activity
- enzyme
- Ring finger domain
- protein binding
- RING-like zinc finger
- RING-type zinc-finger
- PA
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- transmembrane domain
- PHD finger superfamily
- RING-H2 zinc finger domain
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- experimental autoimmune encephalomyelitis
- alcoholic pancreatitis
- acute pancreatitis
- autoimmune disease
- dysferlinopathy
- non-small cell lung carcinoma
- non-small cell lung cancer
role in cell
- expression in
- phosphorylation in
- proliferation
- function
- ubiquitination in
- suppression
- anergy
- conversion
- conjugation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Golgi Apparatus
- Endoplasmic Reticulum
- cytosol
- recycling endosomes
- late endosomes
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rnf128 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of protein stability
- negative regulation of cytokine production
- protein ubiquitination
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- cytoskeleton
- cytoplasm
- membrane
- late endosome
- cytosol
- endoplasmic reticulum
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding