ZMYND11 Gene Summary [Human]
The protein encoded by this gene was first identified by its ability to bind the adenovirus E1A protein. The protein localizes to the nucleus. It functions as a transcriptional repressor, and expression of E1A inhibits this repression. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ZMYND11 |
| Official Name | zinc finger MYND-type containing 11 [Source:HGNC Symbol;Acc:HGNC:16966] |
| Ensembl ID | ENSG00000015171 |
| Bio databases IDs | |
| Aliases | zinc finger MYND-type containing 11 |
| Synonyms | 2210402G22Rik, BS69, MRD30, zinc finger, MYND domain containing 11, zinc finger MYND-type containing 11, zinc finger, MYND-type containing 11 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZMYND11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- PHD zinc finger
- transcription regulator
- MYND finger
- transcription co-repressor
- protein binding activity, bridging
- PWWP domain
- PWWP (Pro-Trp-Trp-Pro) domain
- protein binding
- Bromodomain
- zinc ion binding
- double-stranded DNA binding
- phd-bromo-pwwp domain
- PHD finger superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- lung squamous cell carcinoma
- squamous cell lung cancer
- rheumatoid arthritis
- renal clear cell adenocarcinoma
- renal clear cell cancer
- hereditary disorder
- autosomal dominant mental retardation type 30
- organismal death
- syndromic complex neurodevelopmental disorder
role in cell
- apoptosis
- migration
- retention in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cell periphery
- nucleoplasm
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZMYND11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription, DNA-dependent
- regulation of transcription elongation from RNA polymerase II promoter
- negative regulation of extrinsic apoptotic signaling pathway
- defense response to virus
- negative regulation of I-kappaB kinase/NF-kappaB cascade
- chromatin organization
- negative regulation of JNK cascade
- regulation of signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- transcription corepressor activity
- methylated histone residue binding
- double-stranded DNA binding