Rap1gds1 Gene Summary [Mouse]
Enables GTPase regulator activity. Acts upstream of or within several processes, including angiotensin-activated signaling pathway involved in heart process; negative regulation of GTPase activity; and regulation of matrix metallopeptidase secretion. Located in extracellular space. Is expressed in several structures, including central nervous system; glans of male genital tubercle; lens; liver; and retina nuclear layer. Orthologous to human RAP1GDS1 (Rap1 GTPase-GDP dissociation stimulator 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rap1gds1 |
| Official Name | RAP1, GTP-GDP dissociation stimulator 1 [Source:MGI Symbol;Acc:MGI:2385189] |
| Ensembl ID | ENSMUSG00000028149 |
| Bio databases IDs | |
| Aliases | RAP1, GTP-GDP dissociation stimulator 1 |
| Synonyms | GDS1, Rap1 GTPase-GDP dissociation stimulator 1, RAP1, GTP-GDP dissociation stimulator 1, SmgGDS |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rap1gds1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Armadillo/beta-catenin-like repeat
- GTPase regulator
- highly conserved peptide binding groove
- guanyl-nucleotide exchange factor
- Armadillo/beta-catenin-like repeats
- protein binding
- electronegative surface patch domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- edema
- Alfadhel syndrome
- cyanosis
- congestion
role in cell
- expression in
- proliferation
- apoptosis
- number
- activation in
- production in
- cell death
- morphology
- assembly
- prenylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- Nucleus
- Endoplasmic Reticulum
- Mitochondria
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rap1gds1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- elevation of mitochondrial calcium ion concentration
- regulation of ERK5 cascade
- vascular smooth muscle contraction
- CAAX-box protein maturation
- reduction of endoplasmic reticulum calcium ion concentration
- regulation of mitochondrion organization
- myosin filament assembly
- protein localization to nucleus
- cardiac muscle hypertrophy
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- mitochondrion
- cytosol
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding
- guanyl-nucleotide exchange factor activity