Sox7 Gene Summary [Mouse]
Enables DNA-binding transcription factor activity, RNA polymerase II-specific and transcription cis-regulatory region binding activity. Acts upstream of or within positive regulation of DNA-templated transcription and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; reproductive system; and urinary system. Used to study congenital diaphragmatic hernia. Orthologous to human SOX7 (SRY-box transcription factor 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sox7 |
| Official Name | SRY (sex determining region Y)-box 7 [Source:MGI Symbol;Acc:MGI:98369] |
| Ensembl ID | ENSMUSG00000063060 |
| Bio databases IDs | |
| Aliases | SRY (sex determining region Y)-box 7 |
| Synonyms | SRY-box transcription factor 7, SRY (sex determining region Y)-box 7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sox7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- double-stranded DNA binding
- nucleic acid binding
- high mobility group (HMG)-box domain superfamily
- HMG (high mobility group) box
- HMG-box domain
- high mobility group
- protein binding
- sequence-specific DNA binding
- transcription factor activity
- Sox 17/18 central domain
Pathways
Biological processes and signaling networks where the Sox7 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- breast cancer
- hepatic fibrosis
- liver cirrhosis
- edema
- growth failure
- carbon tetrachloride-induced liver fibrosis
- androgenic alopecia
role in cell
- apoptosis
- expression in
- proliferation
- migration
- phosphorylation in
- pluripotency
- tubulation
- invasion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sox7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
- negative regulation of transcription, DNA-dependent
- negative regulation of cell proliferation
- regulation of canonical Wnt receptor signaling pathway
- cell differentiation
- endoderm formation
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity