Dhps Gene Summary [Mouse]
Enables deoxyhypusine synthase activity. Involved in peptidyl-lysine modification to peptidyl-hypusine. Acts upstream of or within glucose homeostasis and positive regulation of T cell proliferation. Is active in cytosol. Orthologous to human DHPS (deoxyhypusine synthase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dhps |
| Official Name | deoxyhypusine synthase [Source:MGI Symbol;Acc:MGI:2683592] |
| Ensembl ID | ENSMUSG00000060038 |
| Bio databases IDs | |
| Aliases | deoxyhypusine synthase |
| Synonyms | DEOXYHYPUSINE SYNTHASE, DHS, DS, MIG13, NEDSSWI |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dhps often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- deoxyhypusine synthase
- enzyme
- protein binding
- identical protein binding
Pathways
Biological processes and signaling networks where the Dhps gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- cerebral stroke
- acne vulgaris
- stroke
- falciparum malaria
- subarachnoid hemorrhage
- Pneumocystosis jiroveci pneumonia
- brain ischemia
- schizophrenia
- dermatitis herpetiformis
role in cell
- expression in
- proliferation
- production in
- apoptosis
- differentiation
- outgrowth
- molecular cleavage in
- hypusination in
- outgrowth in
- translation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dhps gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glucose homeostasis
- positive regulation of cell proliferation
- spermidine catabolic process
- positive regulation of T cell proliferation
- peptidyl-lysine modification to hypusine
- spermidine metabolic process
- translation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- deoxyhypusine synthase activity