Eci2 Gene Summary [Mouse]
Enables delta(3)-delta(2)-enoyl-CoA isomerase activity. Predicted to be involved in fatty acid beta-oxidation. Located in mitochondrion and peroxisome. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human ECI2 (enoyl-CoA delta isomerase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Eci2 |
| Official Name | enoyl-Coenzyme A delta isomerase 2 [Source:MGI Symbol;Acc:MGI:1346064] |
| Ensembl ID | ENSMUSG00000021417 |
| Bio databases IDs | |
| Aliases | enoyl-Coenzyme A delta isomerase 2 |
| Synonyms | ACBD2, dJ1013A10.3, DRS-1, enoyl-CoA delta isomerase 2, enoyl-CoA δ isomerase 2, enoyl-Coenzyme A delta isomerase 2, enoyl-Coenzyme A δ isomerase 2, HCA88, PECI, Peroxisomal delta3, delta2-enoyl-Coenzyme A isomerase, Peroxisomal enoyl-coa isomerase |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Eci2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- dodecenoyl-CoA D-isomerase
- carbon-carbon double bond transposing intramolecular oxidoreductase
- crotonase-like
- enzyme
- protein binding
- Enoyl-CoA hydratase/isomerase
- ACBP
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Waldenström macroglobulinemia
- gastric adenocarcinoma
- gastric epithelial cancer
- Parkinson disease
- systemic autoimmune syndrome
- Sengers syndrome
regulates
- trans-3-nonenoyl-coenzyme A
- trans-2-nonenoyl coenzyme A
- C12:1 acylcarnitine
- fatty acid
role in cell
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- peroxisomal matrix
- intracellular membrane-bounded organelle
- Mitochondria
- cytosol
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Eci2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- fatty acid beta-oxidation
Cellular Component
Where in the cell the gene product is active
- peroxisome
- intracellular membrane-bounded organelle
- mitochondrion
- membrane
- cytosol
- peroxisomal matrix
Molecular Function
What the gene product does at the molecular level
- protein binding
- fatty-acyl-CoA binding
- dodecenoyl-CoA delta-isomerase activity