Phf20l1 Gene Summary [Mouse]
Predicted to enable methylation-dependent protein binding activity. Predicted to be involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of NSL complex. Is expressed in cortical plate; early conceptus; inner cell mass; and oocyte. Orthologous to human PHF20L1 (PHD finger protein 20 like 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Phf20l1 |
| Official Name | PHD finger protein 20-like 1 [Source:MGI Symbol;Acc:MGI:2444412] |
| Ensembl ID | ENSMUSG00000072501 |
| Bio databases IDs | |
| Aliases | PHD finger protein 20-like 1 |
| Synonyms | CGI-72, E130113K22Rik, PHD finger protein 20-like 1, TDRD20B, URLC1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Phf20l1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein of unknown function (DUF3776)
- PHD zinc finger
- DNA repair protein Crb2 Tudor domain
- CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains
- Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
- PHD finger protein 20-like protein 1
- PHD finger superfamily
- protein binding
- Tudor domain superfamily
- malignant brain tumor (MBT) repeat
- Jumonji domain-containing protein 2A Tudor domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver neoplasia
- epithelial neoplasia
- neoplasia
- liver cancer
- digestive system cancer
- abdominal cancer
- cancer
- epithelial cancer
- cholangiocarcinoma cancer
- bile duct cancer
regulated by
regulates
- SOX2
- agar
role in cell
- growth
- accumulation in
- ubiquitination in
- degradation in
- transformation
- colony formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Phf20l1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of protein catabolic process
- regulation of transcription from RNA polymerase II promoter
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- NSL complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding