Zfp346 Gene Summary [Mouse]
Enables double-stranded RNA binding activity. Acts upstream of or within positive regulation of apoptotic process. Located in nucleolus. Is expressed in several structures, including alimentary system; brain; connective tissue; genitourinary system; and hemolymphoid system. Orthologous to human ZNF346 (zinc finger protein 346). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Zfp346 |
| Official Name | zinc finger protein 346 [Source:MGI Symbol;Acc:MGI:1349417] |
| Ensembl ID | ENSMUSG00000021481 |
| Bio databases IDs | |
| Aliases | zinc finger protein 346 |
| Synonyms | JAZ, Zfp346, zinc finger protein 346 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zfp346 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc-finger double-stranded RNA-binding
- double-stranded RNA binding
- enzyme binding
- U1 zinc finger
- protein binding
- zinc finger domain
- Zinc-finger of C2H2 type
- RNA binding
Pathways
Biological processes and signaling networks where the Zfp346 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insomnia
- uterine leiomyoma
- leiomyomatosis
- menorrhagia
role in cell
- expression in
- apoptosis
- cell cycle progression
- G1 phase
- dephosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- chromosome
- prenucleolar bodies
- nucleoplasm
- nucleoli
- perichromosomal layer
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zfp346 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- miRNA binding
- zinc ion binding
- protein binding
- RNA binding
- double-stranded RNA binding
- enzyme binding